Zonulin: A biomarker and regulator of gastrointestinal tight gap junctions
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Serum zonulin is elevated in women with polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation.
OBJECTIVE Evidence suggests that increased gut permeability may be associated with polycystic ovary syndrome (PCOS). Human zonulin is currently the only physiological mediator known to reversibly regulate gut permeability by disassembling intestinal tight junctions. So far, no data on serum zonulin levels in patients with PCOS are available. This study aimed to determine circulating serum zonul...
متن کاملZonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.
The primary functions of the gastrointestinal tract have traditionally been perceived to be limited to the digestion and absorption of nutrients and to electrolytes and water homeostasis. A more attentive analysis of the anatomic and functional arrangement of the gastrointestinal tract, however, suggests that another extremely important function of this organ is its ability to regulate the traf...
متن کاملCiccia, F. et al. (2017) Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis. Annals of the Rheumatic
Background: Dysbiosis has been recently demonstrated in AS patients but its implications in the modulation of intestinal immune responses have been never studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in Ankylosing Spondylitis (AS). Methods: Ileal biopsies were obtained from 50 HLA-B27 AS patients and 20 normal subj...
متن کاملPLoS Pathog
The anatomical and functional arrangement of the gastrointestinal tract suggests that this organ, beside its digestive and absorptive functions, regulates the trafficking of macromolecules between the environment and the host through a barrier mechanism. Under physiological circumstances, this trafficking is safeguarded by the competency of intercellular tight junctions, structures whose physio...
متن کاملFluctuation of zonulin levels in blood vs stability of antibodies
AIM To evaluate the measurement of zonulin level and antibodies of zonulin and other tight junction proteins in the blood of controls and celiac disease patients. METHODS This study was conducted to assess the variability or stability of zonulin levels vs IgA and IgG antibodies against zonulin in blood samples from 18 controls at 0, 6, 24 and 30 h after blood draw. We also measured zonulin le...
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